For the SURFACE DESIGN project, we sought to quantify and spatialize cellular and tissue contour information using normal human mammary epithelial cells cultivated within a 3-D normal or tumor-like microenvironment. Specifically, the project examined morphogenesis, lumen formation and nuclear packing behavior as a response to alterations in tissue surface design. These parameters were chosen since they represent cardinal features of aggressive forms of this disease. Additionally, these relationships were tested against and funneled through simple architectural and deployable structures. Here, the algorithmic and digital exploration of relationships between interacting cells and their immediate tissue environment gives rise to an abstract, yet deeper understanding of architectural form as it relates to a dynamic boundary condition and existing constraints found within the designed mechanisms of deployable structures. In turn, this information may provide new clues as to how the tissue microenvironment impact cell behavior in breast cancer.
UPenn Dept of ARCH745, Nonlinear Biosynthesis (Sabin & Jones)
Responsive & Packing Based Surface Design
Misako Murata, Austin McIerny, (M.ARCH and L.ARP, 08/09, PennDesign)
Agne Taraseviciuete (IME & University of Colorado MD-PhD Student)