Data extracted from scientific papers and cellular motility videos served as a basis for the study of the relationship between cells and the Extracellular Matrix (ECM) during Motility. More specifically, this research intended to explore the relationship of ECM compliance and actin/cytoskeleton structural changes within the cell. Research has shown that the ECM can influence a cell’s structure and therefore its geometry, motility, and proficiency to adhere to the ECM and this relationship between cellular changes and ECM can have reciprocal affects.
This relationship was explored through the development of a tool that analyzes the relationship of an object moving within an environment over time. While it was directed at information learned from the biological systems studied, it was intended to be applicable for external data sets of various kinds. Of particular interest was the opportunity to look at how human movement is influenced by architectural space.
UPenn Dept of ARCH745, Nonlinear Systems Biology & Design (Sabin & Jones)
Christopher Allen, Benjamin Callam,
& Katherine Mandel