UPenn Dept of ARCH745, Nonlinear Systems Biology & Design (Sabin)
Ikje Cheon, Dane Zeiler, Josef Musil
The complete process of cell motility is quite complex, although we have observed several key features from the provided data sets of human pulmonary artery vascular smooth muscle cells. We have studied the movement of individual cells and witnessed both pulling and pushing motions of the spreading actin filament arms. This movement is often propelled away from a thin and long projection also known as the “tail”. Our process is seeking to understand the associated movements of the cell body in response to tail length. By comparing a single muscle cell across 49 frames in both native and denatured environments, we have derived various data sets. This data informs our research of several important notes. First, we can conclude a difference in taililing behavior in terms of extension length, area, and average angle to extended filopodia. Second, within each cellular environment, there is a continuous pattern of growth and compression of the cell body. Also, the average angle to extended filopodia in the denatured environment is nonlinear across the data set. The design of the research attempts to depict a non-linear relationship between angle, length, and transformation of structure. The design will be applied to the broad networking of the same components where each components can still be manipulated manually. By allowing the control to be also in an angle, not only in a vertical direction, it adds another layer of complexity and dynamic movement.