UPenn Dept of ARCH745, Nonlinear Systems Biology & Design (Sabin)
Bo Rin Jung, Yan Cong, Vivian Liao
Base on the research over cell motility, the intent of this project is to create an environment which can control and deform the shape of the cell in three dimensions through its own reorganization. Starting from visual observation of the film, a computer script is developed to simulate cell deformation during its moving process in two different environment:, native substrate and denatured substrate, based on the observation results and biology study. In the denatured substrate, comparing to the native substrate, cells move faster with less directionality because the adhesion force decreases due to the breakdown of the substrate protein. In the computer simulation, a matrix is set up as an environment, where the cell membrane could move faster and osculate locations marked as denatured points in the environment matrix.